血糖近红外定量分析方法研究

doi:10.16180/j.cnki.issn1007-7820.2020.02.009

电子科技 ›› 2020, Vol. 33 ›› Issue (2): 48-53.doi: 10.16180/j.cnki.issn1007-7820.2020.02.009

血糖近红外定量分析方法研究

胡杰¹,王凯²,王亚刚¹,李文帅³

^1. 上海理工大学光电信息与计算机工程学院,上海 200093
^2. 上海出版印刷高等专科学校印刷设备工程系,上海 200093
^3. 杭州蕙新医疗科技有限公司,浙江杭州 310006

收稿日期:2019-01-13 出版日期:2020-02-15 发布日期:2020-03-12
作者简介:胡杰(1992-),男,硕士研究生。研究方向:检测技术与自动化装置。|王凯(1973-),男,高级工程师。研究方向:工业无线传感器网络、过程控制系统应用。|王亚刚(1967-),男,博士,教授。研究方向:系统辨识、先进过程控制等。
基金资助:
国家自然科学基金(61074087)

Study on Near-infrared Quantitative Analysis of Blood Glucose

HU Jie¹,WANG Kai²,WANG Yagang¹,LI Wenshuai³

^1. School of Optical-Electrical and Computer Engineering,University of Shanghai for Science and Technology
^2. Printing Equipment Engineering,Shanghai Publishing and Printing College,Shanghai 200093,China
^3. Hangzhou Huixin Medical Technology Co., Ltd, Hangzhou 310006,China

Received:2019-01-13 Online:2020-02-15 Published:2020-03-12
Supported by:
National Natural Science Foundation of China(61074087)

摘要/Abstract

摘要：

为解决传统有创检测血糖的问题,文中对近红外光谱无创血糖检测技术进行了研究。使用ABB公司的TALYS ASP531近红外光谱仪测得葡萄糖溶液的光谱,建模波段选取5 500~6 500 cm ^-1,使用偏最小二乘法建立光谱数据与对应浓度之间的校正模型。实验结果表明,校正模型的决定系数达到了0.983 99,校正均方根偏差为1.023 26 mmol·L ^-1,误差分布为-1.3~1.7 mmol·L ^-1,证明了近红外无创检测人体血糖浓度的可行性,为近红外血糖检测的研究提供了可靠的依据。

关键词: 血糖, 近红外光谱, 无创, 葡萄糖溶液, 偏最小二乘法, 主成分回归

Abstract:

In order to solve the problem of traditional invasive blood glucose detection, the noninvasive blood glucose detection technology by near infrared spectroscopy was studied. The near infrared spectra of glucose solution were measured by TALYS ASP531 near infrared spectrometer of ABB Company. The selected modeling band was 5500~6500 cm ^-1 and the calibration model between spectral data and corresponding concentration was established by partial least squares method. According to the experimental results, the determination coefficient of the calibration model reached 0.98399, the root mean square deviation was 1.023 26 mmol·L ^-1, and the error distribution was -1.3~1.7 mmol·L ^-1. The results demonstrated the feasibility of non-invasive detection of human blood glucose concentration by near-infrared, and provided a reliable basis for the study of near-infrared blood glucose detection.

Key words: blood glucose, NIR, noninvasive, glucose solution, PLS, PCR

中图分类号:

TN219

胡杰,王凯,王亚刚,李文帅. 血糖近红外定量分析方法研究[J]. 电子科技, 2020, 33(2): 48-53.

HU Jie,WANG Kai,WANG Yagang,LI Wenshuai. Study on Near-infrared Quantitative Analysis of Blood Glucose[J]. Electronic Science and Technology, 2020, 33(2): 48-53.

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	偏最小二乘法	主成分回归
决定系数	0.983 99	0.971 64
校正均方差	1.023 26	1.365 97
误差范围	-1.3~1.7 mmol·L^-1	-3~2.4 mmol·L^-1
主因子数	6	6

血糖近红外定量分析方法研究

Study on Near-infrared Quantitative Analysis of Blood Glucose

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