螺旋式激发的荧光分子断层成像

doi:10.3969/j.issn.1001-2400.2018.02.017

西安电子科技大学学报

螺旋式激发的荧光分子断层成像

侯榆青;魏红娜;易黄建;张旭;贺小伟

(西北大学信息科学与技术学院，陕西西安 710127)

收稿日期:2017-04-08 出版日期:2018-04-20 发布日期:2018-06-06
作者简介:侯榆青(1963-)，女，教授，E-mail: houyuqin@nwu.edu.cn
基金资助:
国家自然科学基金资助项目(61640418，61372046，11571012)；中国博士后科学基金资助项目(2016M602851)；陕西省教育厅服务地方专项计划资助项目(17JF027)

Imaging system of fluorescence molecular tomography with spiral excitation

HOU Yuqing;WEI Hongna;YI Huangjian;ZHANG Xu;HE Xiaowei

(School of Information Sciences and Technology, Northwest Univ., Xi'an 710127, China)

Received:2017-04-08 Online:2018-04-20 Published:2018-06-06

摘要/Abstract

摘要：

由于在实际中荧光探针的位置是未知的，因此获得的数据会不准确．为了克服这个缺点，提出一种基于螺旋式激发的荧光分子断层成像方式，它能在未知荧光目标具体位置的情况下，保证荧光目标受激发完全，从而确保了测量数据的准确性．通过设计非匀质仿体实验，验证了螺旋式激发方法在荧光分子断层成像中的可行性和有效性．

关键词: 荧光分子断层成像, 螺旋式激发, 成像系统, 图像重建

Abstract:

An imaging system of fluorescence molecular tomography based on spiral excitation is proposed. In the case of unknown specific locations of the fluorescent target, it can ensure that the fluorescent target is fully excited, which guarantees the accuracy of measured data. Heterogeneous phantom experiments have tested the feasibility and effectiveness of this system.

Key words: fluorescence molecular tomography, spiral excitation, imaging systems, image reconstruction

侯榆青;魏红娜;易黄建;张旭;贺小伟. 螺旋式激发的荧光分子断层成像[J]. 西安电子科技大学学报, 2018, 45(2): 97-102.

HOU Yuqing;WEI Hongna;YI Huangjian;ZHANG Xu;HE Xiaowei. Imaging system of fluorescence molecular tomography with spiral excitation[J]. Journal of Xidian University, 2018, 45(2): 97-102.

参考文献

［1］ CHEN D, LIANG J, LI Y, et al. A Sparsity-constrained Preconditioned Kaczmarz Reconstruction Method for Fluorescence Molecular Tomography［J］. Biomed Research International, 2016, 2016: 4504161.
［2］ ZHAO Y, ZHU D, BAIKEJIANG R, et al. 3D Mouse Shape Reconstruction Based on Phase-shifting Algorithm for Fluorescence Molecular Tomography Imaging System［J］. Applied Optics, 2015, 54(32): 9573-9582.
［3］ WANG K, WANG Q, LUO Q, et al. Fluorescence Molecular Tomography in the Second Near-infrared Window［J］. Optics Express, 2015, 23(10): 12669-12679.
［4］周源, 刘飞, 阮秋琦, 等. 基于荧光分子断层成像的多模成像系统研究进展［J］. 国际生物医学工程杂志, 2014, 37(1): 43-48.
ZHOU Yuan, LIU Fei, RUAN Qiuqi, et al. Research Progress in Multi-modality Imaging System Based Oil Fluorescence Molecular Tomography［J］. International Journal of Biomedical Engineering, 2014, 37(1): 43-48.
［5］ BAI J, XU Z. Fluorescence Molecular Tomography［M］. Molecular Imaging Fundamentals and Applications. Heidelberg: Springer, 2012: 185-216.
［6］ LIAN L C, DENG Y, XIE W, et al. Enhancement of the Localization and Quantitative Performance of Fluorescence Molecular Tomography by Using Linear nBorn Method［J］. Optics Express, 2017, 25(3): 2063-2079.
［7］ ZHOU Y, GUANG H , PU H, et al. Unmixing Multiple Adjacent Fluorescent Targets with Multispectral Excited Fluorescence Molecular Tomography［J］. Applied Optics, 2016, 55(18): 4843-4849.
［8］ LIAN L C, DENG Y, XIE W, et al. Enhancement of the Localization and Quantitative Performance of Fluorescence Molecular Tomography by Using Linear nBorn Method［J］. Optics Express, 2017, 25(3): 2063-2079.
［9］ JIANG S, LIU J, AN Y, et al. Novel l 2, 1-norm Optimization Method for Fluorescence Molecular Tomography Reconstruction［J］. Biomedical Optics Express, 2016, 7(6): 2342-2359.
［10］程璟星, 侯榆青, 董芳, 等. 稀疏正则和自适应有限元的荧光分子断层成像［J］. 西安电子科技大学学报, 2015, 42(2): 174-179.
CHENG Jingxing, HOU Yuqing, DONG Fang, et al. Fluorescence Molecular Tomography Based on the Sparse Regularization and Adaptive Finite Element Method［J］. Journal of Xidian University, 2015, 42(2): 174-179.
［11］ HE X W, LIANG J, WANG X, et al. Sparse Reconstruction for Quantitative Bioluminescence Tomography Based on the Incomplete Variables Truncated Conjugate Gradient Method［J］. Optics Express, 2010, 18(24): 24825-24841.
［12］张旭, 易黄建, 侯榆青, 等. 基于局部保留投影的荧光分子断层成像快速重建［J］. 光学学报, 2016, 36(7): 213-222.
ZHANG Xu, YI Huangjian, HOU Yuqing, et al. Fast Reconstruction in Fluorescence Molecular Tomography Based on Locality Preserving Projections［J］. Acta Optica Sinica, 2016, 36(7): 213-222.
［13］ YAO R, PIAN Q, YAO R, et al. Wide-field Fluorescence Molecular Tomography with Compressive Sensing Based Preconditioning［J］. Biomedical Optics Express, 2015, 6(12): 4887-4898.
［14］ AN Y, LIU J, ZHANG G, et al. A Novel Region Reconstruction Method for Fluorescence Molecular Tomography［J］. IEEE Transactions on Biomedical Engineering , 2015, 62(7): 1818-1826.

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螺旋式激发的荧光分子断层成像

Imaging system of fluorescence molecular tomography with spiral excitation

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