Abstract:

In order to solve the problem of privacy leakage in the sharing of genomic data, a genomic data privacy-preserving scheme based on the improved Private Set Intersection (PSI) computing protocol is presented, which leverages the Bloom Filter, Cuckoo Hash, and Random Oblivious Transfer (ROT) extension protocol to not only protect the genomic sequence information on the user when detecting a disease-causing gene but also judge whether he or she has some disease factors or not. Moreover, the correctness and security of the proposed scheme in the detection scenario of disease-causing genes are proved in the semi-honest security model. In addition, a series of experiments is conducted to verify the efficiency of the proposed scheme. The results reveal that the running time and communication overhead of the proposed scheme are much less than those of the existing PSI schemes.

Key words: private set intersection, oblivious transfer, genetic privacy, privacy preserving